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Jul232013

10:54:54 am

Animal Study Raises Safety Questions About Heartburn Drugs








Study: Acid reflux drugs may lead to heart disease






We used several different model systems, including whole human blood vessels, and saw the same effect in each of these situations. In addition, his teams research is consistent with other signals that have been coming from the literature for some time. Cooke is referring to previous studies such as this one, published in the Journal of the Canadian Medical Association , and this one, published in 2011 in the British Medical Journal that have linked PPIs with increased risk of heart attack and heart damage in people whove already had a prior cardiovascular event. These studies have pointed to the possibility that PPIs are interfering with the action of blood thinners such as aspirin and clopidogrel (brand name Plavix), preventing them from performing their important anti-clotting function. At the moment, the American Heart Association considers proton pump inhibitors safe. In 2010, the AHA issued a joint statement with the American College of Cardiology and the American College of Gastroenterology reaffirming the safety of PPIs with clopidogrel and other anti-clotting drugs for people considered at risk for upper GI bleeds. But the professional groups did not recommend routine use of PPIs for patients taking clopidogrel or aspirin. Which Drugs Are Cause for Concern? The most commonly taken PPI drugs are sold over the counter and by prescription, both as brand names and generics. In addition to Prilosec ( AstraZeneca AstraZeneca ), Prevacid (Takeda), and Nexium (AstraZeneca), popular PPI brands include Protonix (Wyeth), Zegerid ( Santarus Santarus ), Aciphex ( Eisai Eisai /Johnson & Johnson), and new arrival Dexilant (Takeda), and generics include lansoprazole, omeprazole, pantoprazole, esomeprazole, and dexlansoprazole. Proton pump inhibitors are very big business; in 2009 they passed cholesterol-lowering medications to become the second-largest class of drugs sold in the U.S. with total sales of 13.6 billion, according to IMS Health. Nexium alone brought $6.3 billion in sales to maker AstraZeneca in 2009. Other Risks from PPIs: According to Consumer Reports , several studies have linked PPIs to a higher risk of pneumonia and infection with the bacteria Clostridium difficile which causes severe diarrhea and intestinal infection, particularly in the elderly. Other studies have linked long-term use of PPIs with an increased risk of fractures. The FDA has issued two warnings for PPIs in the past three years, according to Harvard Health Publications .
For the original version including any supplementary images or video, visit http://www.forbes.com/sites/melaniehaiken/2013/07/12/common-acid-reflux-drugs-could-raise-risk-of-heart-disease-new-research-suggests/












Their acid reflux is that bad. Until now, medication and limited surgical procedures were their only options. However a minimally-invasive surgical option has emerged that promises to correct the problem once and for all, and there's only one Central Texas healthcare system offering the procedure. Life is good these days for D.Y. Cole and his wife Shirley of San Angelo, but a debilitating illness limited laughter over most of the last decade. "We're both vocalists, and I started losing my voice," said D.Y. Cole wasn't suffering from laryngitis but severe heartburn or acid reflux disease. It occurs when stomach contents that are supposed to be going down your digestive system actually go up. "The acid comes up into your throat and into your esophagus," said D.Y. "It bathes your vocal cords. It gets into your throat." "In some patients it actually goes all the way up into their voice box and larynx causing problems with voice irritation and actually goes down into some patients lungs," said F.
For the original version including any supplementary images or video, visit http://www.khou.com/news/215546641.html







LINX magnetic bead procedure promises to rid acid reflux






In a study released last week, researchers found that people taking those reflux medications could have an increased risk of getting heart disease. The drugs in this study are "proton pump inhibitors" or PPI's. They're sold both over the counter and with a prescription. It includes drugs like Prilosec, Prevacid, Nexium, Protonix, Zegerid, Aciphex, Dexilant, plus generic versions of those brand names. The new study, published in the Journal of the American Heart Association, found that these medications can cause blood vessels to constrict and reduce blood flow. That reduced blood flow significantly increases a person's risk of heart disease. News10NBC spoke to a doctor at Rochester General Hospital about what patients taking those PPI's should do. Dr. Jeffrey Goldstein said, "We do have alternatives, but the key thing is not to say I have reflux but I'm not going to take my reflux medicines because it's going to interact potentially with my cardiac medicine.
For the original version including any supplementary images or video, visit http://www.nbcnews.com/id/52483597/ns/local_news-rochester_ny/t/study-acid-reflux-drugs-may-lead-heart-disease/




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